marginal zone lymphoma
Also written as: MZL — marginal zone lymphoma
A group of indolent B-cell lymphomas that arise in mucosa-associated lymphoid tissue, lymph nodes, or spleen.
Full Definition
Marginal zone lymphoma encompasses three distinct subtypes of indolent B-cell lymphomas: extranodal marginal zone lymphoma of mucosa-associated lymphoid tissue (MALT lymphoma), nodal marginal zone lymphoma, and splenic marginal zone lymphoma. These lymphomas arise from post-germinal center B cells located in the marginal zone of lymphoid organs. MALT lymphomas frequently develop in the setting of chronic inflammation or infection, such as Helicobacter pylori gastritis. The lymphomas typically follow an indolent course with a tendency to remain localized for extended periods. Treatment approaches vary by subtype and may include antimicrobial therapy for infection-associated cases, radiation therapy, or systemic therapy.
Usage
Usage note: Specify the subtype (extranodal, nodal, or splenic) when known for clinical precision.
In Context
- "The gastric biopsy confirmed extranodal marginal zone lymphoma associated with H. pylori infection." — pathology report
- "Antibiotic therapy for H. pylori led to regression of the marginal zone lymphoma." — follow-up note