mantle cell lymphoma
Also written as: MCL — mantle cell lymphoma
An aggressive B-cell lymphoma characterized by the t(11;14) translocation and typically presenting with widespread disease at diagnosis.
Full Definition
Mantle cell lymphoma is a distinct B-cell neoplasm characterized by the t(11;14)(q13;q32) translocation leading to cyclin D1 overexpression. The lymphoma cells originate from the mantle zone of lymphoid follicles and typically show a diffuse growth pattern, though nodular and mantle zone patterns may be seen. The disease has an aggressive clinical course with a tendency for widespread dissemination at presentation, frequently involving extranodal sites including the gastrointestinal tract and bone marrow. Treatment typically involves intensive immunochemotherapy regimens, and autologous stem cell transplantation may be considered in appropriate candidates.
Usage
Usage note: Always specify 'mantle cell' to distinguish from other B-cell lymphomas.
In Context
- "Immunohistochemistry confirmed mantle cell lymphoma with strong cyclin D1 expression." — pathology report
- "The patient's mantle cell lymphoma showed gastrointestinal involvement on staging studies." — staging report