monoclonal antibody therapy
Also written as: mAb — monoclonal antibody
Treatment using laboratory-produced antibodies designed to target specific cancer cell antigens.
Full Definition
Monoclonal antibody therapy represents a targeted treatment approach using laboratory-manufactured antibodies that bind to specific antigens expressed on cancer cells. These therapies can work through various mechanisms including direct cell killing, immune system activation, delivery of cytotoxic agents, or blockade of growth signals. Examples in hematologic oncology include rituximab for CD20-positive lymphomas, daratumumab for multiple myeloma, and alemtuzumab for certain leukemias. The specificity of monoclonal antibodies allows for targeted therapy with potentially fewer side effects compared to traditional chemotherapy, though unique toxicities such as infusion reactions and tumor lysis syndrome can occur.
Usage
Usage note: Hyphenate as compound modifier; abbreviate as mAb in appropriate contexts
In Context
- "Monoclonal antibody therapy with rituximab significantly improved outcomes in diffuse large B-cell lymphoma." — Clinical trial results
- "The development of monoclonal antibody therapy revolutionized treatment approaches in hematologic malignancies." — Review article