monoclonal gammopathy
A condition characterized by the presence of abnormal proteins produced by a clone of plasma cells or B lymphocytes.
Full Definition
Monoclonal gammopathy refers to the presence of a monoclonal protein (M protein or paraprotein) in the serum or urine, produced by a single clone of plasma cells or B lymphocytes. This condition encompasses a spectrum from benign monoclonal gammopathy of undetermined significance (MGUS) to malignant conditions such as multiple myeloma, Waldenström macroglobulinemia, and primary amyloidosis. The monoclonal protein is typically detected through serum protein electrophoresis and immunofixation studies. Clinical significance varies widely, with some patients requiring only monitoring while others need immediate treatment.
Usage
Usage note: Often used interchangeably with 'paraproteinemia' though the latter specifically refers to the presence of paraproteins.
In Context
- "Serum protein electrophoresis revealed a monoclonal gammopathy requiring further evaluation." — Laboratory interpretation
- "The distinction between benign and malignant monoclonal gammopathy requires comprehensive clinical assessment." — Diagnostic workup