tyrosine kinase inhibitor
Also written as: TKI — tyrosine kinase inhibitor
A class of targeted cancer drugs that block specific enzymes involved in cancer cell growth, particularly effective in certain blood cancers.
Full Definition
Tyrosine kinase inhibitors (TKIs) are a class of targeted therapy drugs that block the action of tyrosine kinases, enzymes that play crucial roles in cell signaling pathways involved in cell growth and division. In hematologic oncology, TKIs are particularly important for treating chronic myeloid leukemia with the BCR-ABL fusion protein, as well as certain acute leukemias and lymphomas with specific molecular abnormalities. Examples include imatinib, dasatinib, and nilotinib for CML, and ibrutinib for certain B-cell lymphomas.
Usage
Usage note: Hyphenate when used as a compound modifier; TKI is acceptable abbreviation after first use.
In Context
- "The tyrosine kinase inhibitor achieved complete cytogenetic response in most CML patients." — Clinical trial results
- "TKI resistance mechanisms include BCR-ABL mutations and activation of alternative pathways." — Research article