Professional
Technical
IVT
Dexamethasone Suppression Test
Pronunciation: dex-ah-METH-ah-sone
A diagnostic procedure using synthetic corticosteroid to evaluate adrenal function and cortisol production.
Full Definition
The dexamethasone suppression test involves administering synthetic glucocorticoid dexamethasone to suppress normal cortisol production through negative feedback on the hypothalamic-pituitary-adrenal axis. Normal individuals show significant cortisol suppression, while those with Cushing's syndrome or other disorders of cortisol excess may show inadequate suppression. Variants include low-dose overnight, high-dose, and two-day protocols depending on the clinical indication.
Usage
Usage note: Lowercase 'suppression test' unless part of a formal test name.
In Context
- "The overnight dexamethasone suppression test showed inadequate cortisol suppression." — Endocrinology consultation report
- "A high-dose dexamethasone suppression test may help differentiate pituitary from adrenal causes of Cushing's syndrome." — Diagnostic protocol
Also known as
DST
Dex suppression test
Contrasted with
Stimulation test
ACTH stimulation test
Don't confuse with
Cosyntropin stimulation test
Cortisol response test
ACTH test