Professional
Technical
IVT
Tandem Mass Spectrometry
An analytical technique using multiple mass analyzers for highly specific hormone quantification.
Full Definition
Tandem mass spectrometry (MS/MS) employs two or more mass analyzers in sequence to provide exceptional specificity and sensitivity for hormone measurement. The first analyzer selects the target molecule, which is then fragmented, and the second analyzer identifies characteristic fragments. This technique eliminates cross-reactivity issues common in immunoassays and is considered the gold standard for measuring steroid hormones, particularly when concentrations are low or when structural analogs may interfere with immunoassay methods.
Usage
Usage note: Use 'MS/MS' abbreviation; 'LC-MS/MS' includes liquid chromatography separation.
In Context
- "Tandem mass spectrometry provides superior specificity for measuring pediatric hormone levels." — Laboratory methodology comparison
- "The reference laboratory uses LC-MS/MS for accurate testosterone quantification." — Send-out testing protocol
Also known as
MS/MS
LC-MS/MS
Don't confuse with
Single mass spectrometry
Immunoassay
Chromatography