fractional flow reserve
Also written as: FFR — Fractional Flow Reserve
A physiological measurement used to assess the functional significance of coronary artery stenosis.
Full Definition
Fractional flow reserve (FFR) is a diagnostic technique that measures the pressure difference across a coronary stenosis during maximal hyperemia to determine if the blockage significantly impedes blood flow. The measurement involves advancing a pressure wire across the stenosis and administering adenosine to induce maximal coronary vasodilation. An FFR value below 0.80 indicates hemodynamically significant stenosis requiring intervention. This technique helps guide treatment decisions, particularly for intermediate stenoses where visual assessment alone may be inadequate. FFR-guided PCI has been shown to improve clinical outcomes while reducing unnecessary procedures.
Usage
Usage note: Often abbreviated as FFR in clinical contexts. Ensure proper capitalization of abbreviated form.
In Context
- "Fractional flow reserve measurement revealed hemodynamically significant stenosis despite moderate angiographic appearance." — Cardiac catheterization report
- "The FAME trial demonstrated superior outcomes with fractional flow reserve-guided PCI compared to angiography alone." — Clinical guidelines document