fetal fibronectin
Also written as: fFN
Glycoprotein present at the maternal-fetal interface, used as a biomarker for preterm labor risk.
Full Definition
Fetal fibronectin (fFN) is a glycoprotein that acts as an adhesive between the fetal membranes and the decidua. Normally absent from cervicovaginal secretions between 22-37 weeks of gestation, its presence can indicate disruption of the maternal-fetal interface and increased risk of preterm delivery. The fetal fibronectin test is performed by collecting cervicovaginal secretions and has high negative predictive value, meaning a negative test strongly suggests delivery will not occur within the next 7-14 days. This test helps guide management decisions in women with symptoms of preterm labor.
Usage
Usage note: Use fFN abbreviation after first mention; specify timing of test relative to symptoms.
In Context
- "Fetal fibronectin was negative, indicating low risk for delivery within 14 days." — Preterm labor evaluation
- "A positive fFN test prompted administration of antenatal corticosteroids." — High-risk obstetric care