gestational trophoblastic disease
Pronunciation: tro-fo-BLAS-tik
Also written as: GTD — Gestational Trophoblastic Disease
Spectrum of pregnancy-related trophoblastic disorders ranging from benign molar pregnancy to malignant choriocarcinoma.
Full Definition
Gestational trophoblastic disease (GTD) encompasses a spectrum of disorders arising from abnormal proliferation of placental trophoblastic tissue. The spectrum includes complete and partial molar pregnancies (hydatidiform mole), invasive mole, choriocarcinoma, and placental site trophoblastic tumor. GTD is characterized by elevated beta-hCG levels and requires careful monitoring and potential chemotherapy treatment. Complete moles carry risk of malignant transformation, while partial moles rarely become malignant.
Usage
Usage note: GTD includes both benign and malignant forms; specify subtype when known.
In Context
- "Serial beta-hCG monitoring is essential following evacuation of gestational trophoblastic disease." — Follow-up care protocol
- "The ultrasound findings of a 'snowstorm' pattern suggested complete molar pregnancy within the GTD spectrum." — Diagnostic imaging report