tocolysis
Pronunciation: TOH-koh-lie-sis
The use of medications to suppress uterine contractions and delay preterm labor.
Full Definition
Tocolysis refers to the pharmacological suppression of uterine contractions to delay preterm delivery and allow time for interventions that improve neonatal outcomes. Common tocolytic agents include nifedipine (calcium channel blocker), indomethacin (NSAID), magnesium sulfate, and beta-agonists like terbutaline. The primary goal is not to prevent preterm delivery indefinitely but to gain 48-72 hours for antenatal corticosteroid administration and, if necessary, maternal transfer to a facility with appropriate neonatal care capabilities. Tocolysis is most effective when initiated early in preterm labor and is contraindicated in certain conditions such as chorioamnionitis, severe preeclampsia, or significant bleeding. The choice of agent depends on gestational age, contraindications, and institutional protocols.
Usage
Usage note: Plural form is tocolyses; adjective form is tocolytic.
In Context
- "Tocolysis with nifedipine was initiated to allow completion of the steroid course." — Preterm labor management
- "Contraindications to tocolysis included suspected chorioamnionitis and advanced cervical dilation." — Clinical decision documentation