cytokine release syndrome
Systemic inflammatory response caused by immune activation from certain cancer treatments.
Full Definition
Cytokine release syndrome (CRS) is a systemic inflammatory response syndrome caused by widespread activation of immune cells, leading to massive release of cytokines. In oncology, CRS is most commonly associated with immunotherapies such as CAR-T cell therapy and some monoclonal antibodies. Symptoms range from mild flu-like illness to severe multi-organ dysfunction including high fever, hypotension, and respiratory distress. Management involves supportive care and anti-inflammatory medications such as tocilizumab. Early recognition and intervention are crucial for patient safety.
Usage
Usage note: Often abbreviated as CRS; distinguish from sepsis which has infectious etiology.
In Context
- "The patient developed grade 2 cytokine release syndrome following CAR-T cell infusion." — Immunotherapy monitoring report
- "Tocilizumab was administered to manage severe cytokine release syndrome symptoms." — Emergency treatment record