epithelial-mesenchymal transition
Also written as: EMT — epithelial-mesenchymal transition
Cellular process where epithelial cells acquire mesenchymal characteristics, promoting cancer invasion and metastasis.
Full Definition
Epithelial-mesenchymal transition (EMT) is a fundamental biological process where epithelial cells lose their characteristic features and acquire mesenchymal properties. In cancer, EMT enables tumor cells to become more invasive, resist apoptosis, and gain stem-cell-like properties that facilitate metastasis. The process involves loss of cell-cell adhesion, increased motility, and resistance to therapy. EMT markers include decreased E-cadherin expression and increased vimentin, Snail, or Twist expression. Understanding EMT pathways has led to targeted therapeutic approaches and biomarker development.
Usage
Usage note: Commonly abbreviated as EMT - ensure context distinguishes from emergency medical technician.
In Context
- "Tumor samples showed evidence of epithelial-mesenchymal transition with loss of E-cadherin expression." — Pathology report
- "The research focused on EMT inhibitors as potential therapeutic targets." — Clinical trial protocol