Professional
Technical
IVT
FISH
Also written as: FISH — fluorescence in situ hybridization
Fluorescence in situ hybridization, a molecular technique to detect genetic abnormalities in cancer cells.
Full Definition
Fluorescence in situ hybridization (FISH) is a cytogenetic technique that uses fluorescent probes to detect specific DNA sequences on chromosomes. In oncology, FISH is commonly used to identify genetic alterations such as gene amplifications, deletions, or translocations that drive cancer development. This technique is particularly valuable for diagnosing certain cancers, determining prognosis, and selecting appropriate targeted therapies based on the tumor's genetic profile.
Usage
Usage note: Always capitalize all letters when referring to the technique.
In Context
- "FISH testing confirmed HER2 amplification in the breast cancer specimen." — Pathology report
- "The FISH assay detected the characteristic BCR-ABL fusion gene." — Laboratory report
Also known as
fluorescence in situ hybridization
Don't confuse with
IHC
PCR