FOLFOX
Pronunciation: FOL-fox
Also written as: FOLFOX — folinic acid, fluorouracil, oxaliplatin
A chemotherapy regimen combining folinic acid, fluorouracil, and oxaliplatin.
Full Definition
FOLFOX is a widely used chemotherapy protocol primarily employed in colorectal cancer treatment, combining folinic acid (leucovorin), fluorouracil (5-FU), and oxaliplatin. This regimen is administered intravenously over specific time intervals and cycles. FOLFOX demonstrates efficacy in both adjuvant and metastatic settings for colorectal cancer and may be used in other gastrointestinal malignancies. The regimen has several variations (FOLFOX4, FOLFOX6, modified FOLFOX6) with different dosing schedules. Documentation must specify the exact FOLFOX variant and cycle number for proper treatment tracking.
Usage
Usage note: Specify the FOLFOX variant (FOLFOX4, FOLFOX6, etc.) and cycle number in treatment documentation.
In Context
- "The patient completed six cycles of modified FOLFOX6 chemotherapy." — Treatment summary
- "FOLFOX-induced peripheral neuropathy improved three months after treatment completion." — Follow-up note