sanctuary site
Anatomical locations where systemic therapies have limited penetration, potentially harboring residual cancer cells.
Full Definition
Sanctuary sites are anatomical locations where systemically administered anticancer drugs achieve subtherapeutic concentrations due to pharmacokinetic barriers. The most well-known sanctuary site is the central nervous system, protected by the blood-brain barrier. Other examples include the testes and certain ocular compartments. These sites can harbor residual cancer cells despite apparent systemic disease control, potentially leading to isolated relapses. Recognition of sanctuary sites influences treatment planning and may require specialized approaches such as intrathecal therapy or radiation.
Usage
Usage note: Used specifically in oncology context to describe pharmacokinetic limitations, not general anatomy.
In Context
- "CNS prophylaxis was administered due to concern for sanctuary site relapse." — treatment protocol
- "The blood-brain barrier creates a sanctuary site for circulating tumor cells." — clinical review