tocolysis
Pronunciation: toh-KOL-ih-sis
Medical intervention to suppress premature uterine contractions and delay preterm delivery.
Full Definition
Tocolysis refers to the medical management aimed at suppressing uterine contractions to prevent or delay preterm labor and delivery. Common tocolytic agents include magnesium sulfate, calcium channel blockers like nifedipine, and beta-agonists such as terbutaline. The primary goal is to prolong pregnancy long enough to administer corticosteroids for fetal lung maturity and arrange transfer to a facility with appropriate neonatal intensive care capabilities. Tocolysis is typically considered for pregnancies between 24-34 weeks gestation, though the specific window may vary based on institutional protocols. Success of tocolytic therapy can significantly impact neonatal outcomes by allowing additional time for in-utero development. However, tocolysis is contraindicated in certain conditions such as severe preeclampsia, placental abruption, or fetal distress.
Usage
Usage note: Critical intervention that directly impacts NICU admissions and neonatal outcomes.
In Context
- "Tocolysis with magnesium sulfate was initiated to delay delivery while betamethasone was administered for lung maturity." — Maternal-fetal medicine consultation
- "The patient responded well to tocolytic therapy, with contractions stopping after 48 hours of treatment." — Obstetric progress note