Intermediate
Technical
IVT
cutoff value
Laboratory threshold used to distinguish normal from abnormal newborn screening results for each tested condition.
Full Definition
Cutoff values are statistically derived thresholds that determine when a newborn screening result requires follow-up action. These values are typically set at the 99th or 99.5th percentile of the normal population distribution for each analyte, balancing sensitivity (detecting affected infants) with specificity (minimizing false positives). Cutoffs vary by laboratory, analytical method, and population demographics, requiring periodic review and adjustment based on program outcomes.
Usage
Usage note: Ensure correct units and reference population when citing cutoff values.
In Context
- "The laboratory lowered the TSH cutoff value after missing two cases of congenital hypothyroidism." — Quality assurance report
- "Seasonal cutoff value adjustments account for temperature-related shipping effects." — Laboratory procedure
Also known as
screening threshold
decision limit
action level
Don't confuse with
reference range
diagnostic threshold