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Professional Technical IVT

SCAD

Pronunciation: S-cad

Also written as: SCAD — short-chain acyl-CoA dehydrogenase deficiency

Short-chain acyl-CoA dehydrogenase deficiency, a fatty acid oxidation disorder of uncertain clinical significance.

Full Definition

Short-chain acyl-CoA dehydrogenase deficiency (SCAD) is a fatty acid oxidation disorder characterized by impaired breakdown of short-chain fatty acids. Unlike other fatty acid oxidation disorders, SCAD often presents with mild or no symptoms, leading to debate about its clinical significance. Many individuals with biochemical SCAD remain asymptomatic throughout life, complicating decisions about inclusion in newborn screening panels and clinical management approaches.

Usage

Usage note: Note uncertain clinical significance when discussing with families.

In Context

  • "SCAD was detected through elevated C4 acylcarnitine but the infant remained asymptomatic." — Follow-up evaluation
  • "The clinical significance of SCAD continues to be debated in the metabolic genetics community." — Literature review

Also known as

short-chain acyl-CoA dehydrogenase deficiency ACADS deficiency

Don't confuse with

MCADD VLCADD other fatty acid oxidation disorders
RUSP ← Back to glossary SCID

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