SCID
Pronunciation: S-C-I-D
Also written as: SCID — severe combined immunodeficiency
Severe combined immunodeficiency, a group of genetic disorders causing absent or severely compromised immune function.
Full Definition
Severe combined immunodeficiency encompasses a heterogeneous group of genetic disorders characterized by profound defects in T-cell function and often B-cell and NK-cell function as well. Affected infants have virtually no functional immune system and are susceptible to life-threatening infections from normally harmless organisms. SCID is detected through newborn screening by measuring T-cell receptor excision circles (TRECs), which reflect T-cell production. Early diagnosis through screening allows for prompt protective isolation and curative treatments such as hematopoietic stem cell transplantation.
Usage
Usage note: Pronounce as individual letters, not as a word. Avoid the outdated term 'bubble boy disease' in professional contexts.
In Context
- "The addition of SCID screening to the newborn screening panel has enabled earlier detection and improved survival rates." — Immunology research publication
- "Infants with suspected SCID require immediate isolation and urgent immunological evaluation following abnormal screening results." — Emergency pediatric protocol