TRECs
Pronunciation: T-RECs
Also written as: TRECs — T-cell receptor excision circles
T-cell receptor excision circles, DNA byproducts measured in newborn screening to assess T-cell production and detect SCID.
Full Definition
T-cell receptor excision circles are circular DNA segments created during T-cell receptor gene rearrangement in developing T-cells within the thymus. These stable DNA molecules serve as biomarkers of recent thymic T-cell production and are measured in dried blood spots from newborns to screen for severe combined immunodeficiency (SCID) and other T-cell defects. Low or absent TRECs indicate impaired T-cell production and trigger further immunological evaluation. The TREC assay has revolutionized early detection of primary immunodeficiencies.
Usage
Usage note: Capitalize all letters. Can be pronounced as 'T-RECs' or spelled out as individual letters.
In Context
- "The TREC assay demonstrated undetectable levels, prompting immediate referral to pediatric immunology for SCID evaluation." — Laboratory screening report
- "Quality control measures for TREC testing include regular calibration with known positive and negative samples." — Laboratory quality manual