1p/19q codeletion
A chromosomal alteration involving loss of chromosome arms 1p and 19q, serving as a key diagnostic and prognostic biomarker in oligodendrogliomas.
Full Definition
The 1p/19q codeletion refers to the simultaneous loss of the short arm of chromosome 1 (1p) and the long arm of chromosome 19 (19q). This genetic alteration is a defining characteristic of oligodendrogliomas and is associated with significantly better prognosis and increased sensitivity to chemotherapy and radiation therapy. The codeletion is detected through fluorescence in situ hybridization (FISH) or chromosomal microarray analysis and is now incorporated into the WHO classification criteria for oligodendrogliomas. Tumors with this codeletion typically show prolonged overall survival and enhanced response to PCV chemotherapy regimens.
Usage
Usage note: Use forward slash in '1p/19q' not hyphen; specify testing method when reporting results.
In Context
- "FISH analysis revealed 1p/19q codeletion, confirming the oligodendroglial lineage." — molecular pathology report
- "Patients with 1p/19q codeleted tumors showed median survival exceeding 15 years." — clinical research paper