ganglioglioma
Pronunciation: GANG-glee-oh-gly-OH-mah
A mixed neuronal-glial tumor typically WHO Grade I, commonly presenting with seizures and showing characteristic biphasic histology with both neuronal and glial components.
Full Definition
Ganglioglioma is a rare, usually benign brain tumor (WHO Grade I) composed of both neoplastic neurons (ganglion cells) and glial cells, most commonly astrocytes. These tumors predominantly affect children and young adults and are strongly associated with intractable epilepsy, particularly temporal lobe epilepsy. Gangliogliomas typically arise in the temporal lobe but can occur throughout the central nervous system. Histologically, they show a biphasic pattern with dysplastic ganglion cells and a glial component that may show varying degrees of anaplasia. Complete surgical resection is often curative and frequently provides excellent seizure control. A small percentage may undergo anaplastic transformation, particularly the glial component, requiring more aggressive treatment approaches.
Usage
Usage note: Often associated with epilepsy surgery; distinguish from gangliocytoma (purely neuronal).
In Context
- "The temporal lobe ganglioglioma was completely resected, resulting in immediate seizure freedom postoperatively." — Surgical outcome report
- "Neuropathological examination revealed a ganglioglioma with prominent ganglion cells and a low-grade astrocytic component." — Pathology report