Skip to main content
Advanced Technical IVT

MGMT methylation status

Also written as: MGMT — O6-methylguanine-DNA methyltransferase

A biomarker that predicts response to alkylating chemotherapy, requiring careful editorial attention to statistical reporting.

Full Definition

MGMT (O6-methylguanine-DNA methyltransferase) methylation status refers to the epigenetic silencing of the MGMT gene through promoter hypermethylation. This biomarker is crucial in glioblastoma treatment decisions as methylated MGMT promoters correlate with better response to temozolomide therapy. Editors must understand the distinction between methylated and unmethylated status, ensure accurate reporting of percentages in patient populations, and correctly present the implications for treatment selection and prognosis.

Usage

Usage note: Always specify 'methylated' or 'unmethylated' status; avoid using MGMT alone when referring to methylation status.

In Context

  • "Patients with methylated MGMT promoter status showed significantly improved overall survival." — Clinical trial results
  • "MGMT methylation status was determined using quantitative methylation-specific PCR." — Methods section of research paper

Also known as

MGMT promoter methylation MGMT hypermethylation status

Contrasted with

MGMT unmethylated status

Don't confuse with

MGMT expression level MGMT mutation status
methylguanine-DNA methyltransferase ← Back to glossary molecular pathology

Editors from these organisations have used our services since 1998

Reuters BBC Oxford University Press Penguin Random House Springer Microsoft Suncor Energy United Nations Fisher Investments IBM The Home Depot KODAK CHEVRON