Pseudopalisading
Pronunciation: SOO-doh-pal-ih-SAYD-ing
Characteristic microscopic pattern of cellular arrangement around necrotic areas, particularly seen in glioblastomas.
Full Definition
Pseudopalisading refers to a distinctive histological pattern characterized by elongated tumor cells arranged in a fence-like formation around areas of necrosis, most commonly observed in glioblastoma multiforme. This microscopic feature represents hypoxic adaptation where tumor cells migrate away from necrotic zones while maintaining cellular density. The presence of pseudopalisading necrosis is one of the defining histological criteria for glioblastoma diagnosis according to WHO classification. In pathology reports, this finding helps distinguish glioblastoma from lower-grade astrocytic tumors and carries important prognostic implications. Editors should recognize this as a specific pathological term that requires precise usage in diagnostic contexts.
Usage
Usage note: Specific histological feature; critical for glioblastoma diagnosis.
In Context
- "Microscopic examination revealed pseudopalisading necrosis characteristic of glioblastoma." — Pathology report
- "The presence of pseudopalisading around necrotic foci supports the diagnosis of grade IV astrocytoma." — Neuropathology consultation