supratentorial primitive neuroectodermal tumor
Pronunciation: soo-prah-ten-TOR-ee-al
Also written as: sPNET — supratentorial primitive neuroectodermal tumor
An aggressive embryonal brain tumor occurring above the tentorium cerebelli, now classified as CNS embryonal tumor NOS in current WHO classification.
Full Definition
Supratentorial primitive neuroectodermal tumor (sPNET) was historically classified as a distinct embryonal brain tumor occurring in the cerebral hemispheres above the tentorium cerebelli. These highly malignant tumors primarily affected children and were characterized by small, round blue cells with high mitotic activity and tendency for CSF dissemination. However, the 2016 WHO classification has largely abandoned the sPNET category, reclassifying most of these tumors as either CNS embryonal tumor, NOS, or other specific entities based on molecular characteristics. The tumors that were previously called sPNET are now recognized to be molecularly heterogeneous, requiring comprehensive molecular profiling for accurate diagnosis and treatment planning.
Usage
Usage note: Historical term now largely obsolete; use current WHO classification terminology.
In Context
- "The tumor previously classified as supratentorial primitive neuroectodermal tumor now requires molecular characterization for accurate diagnosis." — Pathology consultation
- "Historical cases of supratentorial primitive neuroectodermal tumor are being reclassified based on updated WHO criteria." — Research protocol