cerebellar liponeurocytoma
Pronunciation: LIP-oh-new-roh-sy-TOH-mah
A rare cerebellar tumor combining features of neurocytoma and lipomatous differentiation, typically occurring in adults.
Full Definition
Cerebellar liponeurocytoma is a rare, WHO grade II tumor that combines features of central neurocytoma with mature adipose tissue. These tumors typically occur in adults and are almost exclusively located in the cerebellum. Histologically, they consist of small round cells with features similar to central neurocytoma, intermixed with mature fat cells and occasional larger ganglioid cells. The neuronal component expresses synaptophysin and may show Homer Wright rosettes. The presence of mature adipose tissue is a defining feature that distinguishes this entity from conventional central neurocytoma. Despite the WHO grade II designation, these tumors generally have a favorable prognosis following surgical resection.
Usage
Usage note: Extremely rare tumor; adipose tissue component is pathognomonic when combined with neurocytoma features.
In Context
- "The cerebellar mass showed characteristic neurocytoma features with interspersed mature adipose tissue diagnostic of cerebellar liponeurocytoma." — Neuropathology report
- "The combination of neuronal differentiation and lipomatous elements confirmed the diagnosis of cerebellar liponeurocytoma." — Pathology consultation