central neurocytoma
Pronunciation: new-roh-sy-TOH-mah
A benign neuronal tumor typically located in the lateral ventricles with characteristic perinuclear halos and neuropil-like matrix.
Full Definition
Central neurocytoma is a benign, WHO grade II neuronal tumor that typically arises within the lateral ventricles, often attached to the septum pellucidum. Histologically, it consists of uniform small round cells with perinuclear halos (resembling oligodendroglioma) set in a fine fibrillary matrix resembling neuropil. The tumor cells express neuronal markers including synaptophysin and may form Homer Wright rosettes. Despite the WHO grade II designation, central neurocytomas generally have an excellent prognosis following complete surgical resection. The tumor typically affects young adults and can cause obstructive hydrocephalus due to its intraventricular location.
Usage
Usage note: Synaptophysin positivity is key for diagnosis; excellent prognosis despite WHO grade II designation.
In Context
- "The intraventricular tumor showed characteristic perinuclear halos and synaptophysin positivity consistent with central neurocytoma." — Neuropathology report
- "Central neurocytoma was distinguished from oligodendroglioma by its intraventricular location and neuronal immunoprofile." — Pathology consultation