diffuse intrinsic pontine glioma
Also written as: DIPG — diffuse intrinsic pontine glioma
Aggressive brainstem tumor primarily affecting children, characterized by infiltrative growth within the pons.
Full Definition
Diffuse intrinsic pontine glioma (DIPG) is a highly aggressive brain tumor that arises within the pons, predominantly affecting pediatric patients. These tumors are characterized by their infiltrative growth pattern that makes surgical resection impossible. Most DIPGs harbor H3K27M mutations and are now classified as diffuse midline gliomas. The diagnosis is typically made based on characteristic MRI findings and clinical presentation, often without tissue confirmation due to the high surgical risk.
Usage
Usage note: Commonly abbreviated as DIPG in clinical contexts; avoid using 'brainstem glioma' as generic term.
In Context
- "The MRI findings were consistent with diffuse intrinsic pontine glioma, precluding surgical intervention." — Radiological report
- "Tissue diagnosis confirmed DIPG with H3K27M mutation in this pediatric patient." — Neuropathology report