dysembryoplastic neuroepithelial tumor
Pronunciation: dis-em-bree-oh-PLAS-tik new-roh-ep-ih-THEE-lee-al
A benign cortical tumor associated with intractable epilepsy, characterized by multinodular architecture and floating neurons.
Full Definition
Dysembryoplastic neuroepithelial tumor (DNT) is a benign, WHO grade I tumor that typically presents in children and young adults with intractable epilepsy. These tumors are characterized by a multinodular architecture with a specific glioneuronal element consisting of columns of bundled axons lined by oligodendroglia-like cells, creating a 'floating neuron' appearance. DNTs are cortically based and often show a soap-bubble or multicystic appearance on imaging. The tumor may contain mature neurons, astrocytes, and oligodendroglia-like cells in various proportions. Complete surgical resection often results in seizure freedom and excellent long-term prognosis.
Usage
Usage note: Strongly associated with pharmaco-resistant epilepsy; surgical resection often curative for seizures.
In Context
- "The cortical lesion showed characteristic multinodular architecture with floating neurons typical of dysembryoplastic neuroepithelial tumor." — Epilepsy surgery pathology report
- "DNT was suspected given the patient's longstanding temporal lobe epilepsy and characteristic MRI appearance." — Presurgical evaluation note