Professional Technical IVT

EGFR amplification

Also written as: EGFR — Epidermal Growth Factor Receptor amplification

Increased copy number of the epidermal growth factor receptor gene, commonly found in glioblastoma. Key molecular marker for tumor classification and prognosis.

Full Definition

EGFR amplification refers to the increased copy number of the epidermal growth factor receptor gene (EGFR), which is one of the most common molecular alterations in glioblastoma, particularly in primary (de novo) glioblastomas. This amplification typically occurs in IDH-wildtype tumors and is associated with aggressive tumor behavior and poor prognosis. The amplification can be detected through various molecular techniques including fluorescence in situ hybridization (FISH) and next-generation sequencing. Understanding this molecular marker is essential for accurate tumor classification according to current WHO guidelines and for potential targeted therapeutic approaches.

Usage

Usage note: Distinguish from EGFR overexpression, which refers to protein levels rather than gene copy number.

In Context

"FISH analysis revealed EGFR amplification in 65% of the glioblastoma cases." — Molecular pathology report
"The tumor showed classic features of IDH-wildtype glioblastoma with EGFR amplification." — Diagnostic summary

Also known as

EGFR gene amplification

Contrasted with

EGFR deletion

Don't confuse with

EGFR mutation EGFR overexpression

dysmyelination ← Back to glossary EMA staining