EMA staining

Full Definition

EMA staining refers to immunohistochemical detection of epithelial membrane antigen, a glycoprotein expressed on the surface of epithelial cells and certain neural tissues. In neuropathology, EMA is particularly useful for identifying ependymal cells and their neoplastic counterparts, showing characteristic dot-like paranuclear positivity in ependymomas. The staining pattern helps differentiate ependymomas from other glial tumors and is part of the standard immunohistochemical panel for brain tumor diagnosis.

Usage

Usage note: Specify staining pattern (dot-like, diffuse, etc.) when describing results.

In Context

• "EMA staining showed characteristic paranuclear dots, supporting the diagnosis of ependymoma." — Immunohistochemistry report
• "The tumor cells were positive for EMA with the typical dot-like pattern seen in ependymal neoplasms." — Pathology consultation