Hirano body
Pronunciation: hee-RAH-no
Eosinophilic, rod-shaped cytoplasmic inclusion containing actin filaments, characteristically found in neurons of patients with Alzheimer's disease.
Full Definition
An intraneuronal cytoplasmic inclusion body first described by Asao Hirano, composed primarily of actin filaments arranged in a paracrystalline lattice pattern. These structures appear as elongated, eosinophilic rods in routine H&E staining and are most commonly observed in pyramidal neurons of the hippocampus, particularly in CA1 and subiculum regions. While originally associated with Alzheimer's disease, Hirano bodies are now recognized in various neurodegenerative conditions and normal aging. For editors reviewing neuropathology manuscripts, proper capitalization of the eponymous term and accurate description of their ultrastructural features are essential.
Usage
Usage note: Capitalize as an eponymous term; plural form is 'Hirano bodies'.
In Context
- "Hirano bodies were identified in 67% of cases using electron microscopy." — Results section
- "The distinction between Hirano bodies and other cytoplasmic inclusions requires careful morphological assessment." — Discussion section