Professional
Technical
IVT
Homer Wright rosette
Circular arrangement of tumor cells around a central fibrillary space, characteristic of primitive neuroectodermal tumors.
Full Definition
A specific histological pattern characterized by tumor cells arranged in a circular fashion around a central tangle of neural filaments, creating a rosette-like structure. This pattern is classically associated with primitive neuroectodermal tumors (PNETs), medulloepitheliomas, and other embryonal CNS tumors. The central space contains neural filaments rather than being truly empty, distinguishing it from other rosette types such as ependymal rosettes. Recognition of this pattern is crucial for accurate tumor classification.
Usage
Usage note: Named after James Homer Wright; always capitalize both names when used as eponym.
In Context
- "Multiple Homer Wright rosettes were identified, supporting the diagnosis of primitive neuroectodermal tumor." — Pediatric neuropathology report
- "The tumor showed focal formation of Homer Wright rosettes with characteristic central fibrillary material." — Consultation report
Also known as
neural rosette
primitive rosette
Don't confuse with
ependymal rosette
Flexner-Wintersteiner rosette