Professional
Technical
IVT
isocitrate dehydrogenase wild-type
Absence of IDH1 or IDH2 mutations in gliomas, associated with more aggressive behavior and worse prognosis.
Full Definition
The normal, unmutated form of isocitrate dehydrogenase genes (IDH1 and IDH2) in brain tumors. IDH wild-type status in diffuse gliomas is associated with more aggressive biological behavior, resistance to therapy, and significantly worse prognosis compared to IDH-mutant tumors. Most primary glioblastomas are IDH wild-type, while secondary glioblastomas and lower-grade diffuse gliomas more commonly harbor IDH mutations. This molecular distinction is fundamental to current brain tumor classification and treatment stratification.
Usage
Usage note: Hyphenate when used as adjective (IDH wild-type glioma); space when used as noun (IDH wild type).
In Context
- "The glioblastoma was confirmed to be IDH wild-type, consistent with primary glioblastoma." — Molecular classification report
- "IDH wild-type status portended a poor prognosis despite maximal surgical resection." — Clinical correlation
Also known as
IDH wild-type
IDH-wildtype
Contrasted with
IDH-mutant
Don't confuse with
IDH-mutant
IDH1 R132H