neuropathological examination
Systematic microscopic and macroscopic evaluation of nervous system tissue to diagnose disease. Encompasses gross examination, histological analysis, and molecular testing.
Full Definition
Neuropathological examination is a comprehensive diagnostic process that involves the systematic evaluation of nervous system tissue through multiple analytical approaches. This includes initial gross examination of brain and spinal cord specimens, followed by detailed microscopic analysis of histological sections stained with various techniques. Modern neuropathological examination also incorporates immunohistochemical staining, molecular genetic testing, and when appropriate, electron microscopy. The examination follows standardized protocols to ensure accurate diagnosis of neurodegenerative diseases, tumors, infectious processes, and other neurological conditions. Results form the basis for clinical correlation and treatment planning.
Usage
Usage note: Refers to the pathologist's analysis, not the clinician's neurological examination of the patient.
In Context
- "The neuropathological examination revealed extensive tau pathology consistent with Alzheimer disease." — Autopsy report
- "Complete neuropathological examination including molecular studies was requested for tumor classification." — Pathology requisition