neuropil
Pronunciation: NYOOR-oh-pill
The dense network of neural processes (axons, dendrites) between cell bodies in brain tissue.
Full Definition
The intricate meshwork of unmyelinated axons, dendrites, and glial processes that fills the spaces between neuronal cell bodies in gray matter. In neuropathological examination, the neuropil appears as the background eosinophilic (pink) material in H&E-stained sections. Changes in neuropil density, organization, or staining characteristics can indicate various pathological processes including ischemia, degeneration, or inflammation. The term is essential for describing the microscopic architecture of brain tissue in pathology reports.
Usage
Usage note: Distinguish from white matter tracts and neuronal cell bodies in descriptive contexts.
In Context
- "The neuropil showed vacuolation consistent with spongiform change." — neuropathology report
- "Reduced neuropil density was evident in areas of chronic ischemia." — autopsy findings