perineuronal satellite
Glial cell positioned closely around a neuron, often indicating pathological change or response to injury.
Full Definition
A glial cell, typically an oligodendrocyte or astrocyte, that is closely apposed to a neuronal cell body in pathological conditions. This arrangement differs from normal glial-neuronal relationships and often indicates neuronal stress, ischemia, or degenerative processes. The presence of perineuronal satellites is a key histopathological finding that editors must distinguish from normal perineuronal oligodendrocytes.
Usage
Usage note: Not to be confused with satellitosis, which refers to a specific pattern of glial cell clustering.
In Context
- "The cortical biopsy revealed numerous perineuronal satellites surrounding pyramidal neurons in layer III." — Neuropathology report
- "Perineuronal satellite formation was evident in areas of acute ischemic change." — Autopsy findings