perineuronal net
Specialized extracellular matrix structure that surrounds certain neurons, particularly involved in synaptic plasticity and neural protection.
Full Definition
A lattice-like extracellular matrix structure composed primarily of chondroitin sulfate proteoglycans that enwraps the cell body and proximal dendrites of specific neurons. These nets are particularly prominent around parvalbumin-positive interneurons and play crucial roles in regulating synaptic plasticity, ion homeostasis, and neuroprotection. In neuropathological examination, alterations in perineuronal nets are associated with various neurological and psychiatric disorders, making them important markers for editorial review of research manuscripts.
Usage
Usage note: Often abbreviated as PNN in subsequent mentions within the same document.
In Context
- "The perineuronal nets showed significant degradation in the hippocampal CA1 region of Alzheimer's disease specimens." — Research manuscript
- "Lecticans are major components of perineuronal nets and require careful antibody validation in immunostaining protocols." — Methods section