cortical laminar necrosis
Pronunciation: LAM-ih-nar
Selective neuronal death affecting specific cortical layers, appearing as cortical T1 hyperintensity on MRI.
Full Definition
Cortical laminar necrosis represents selective neuronal death that typically affects layers 3, 5, and 6 of the cerebral cortex, most commonly following ischemic injury. On MRI, this appears as characteristic T1 hyperintensity along the cortical ribbon, typically becoming apparent days to weeks after the initial insult. The T1 shortening is thought to be due to lipid-laden macrophages and protein denaturation within necrotic tissue. This finding is most commonly seen following stroke but can also occur with other causes of cortical injury such as status epilepticus, hypoglycemia, or carbon monoxide poisoning.
Usage
Usage note: Specify timing relative to initial injury; indicates irreversible neuronal damage.
In Context
- "T1 hyperintensity along the cortical ribbon was consistent with cortical laminar necrosis." — Subacute stroke MRI report
- "The cortical laminar necrosis pattern suggested irreversible neuronal injury." — Follow-up imaging interpretation