kindling
A phenomenon where repeated subthreshold electrical stimuli eventually trigger spontaneous seizures, modeling epilepsy development.
Full Definition
Kindling is an experimental paradigm in which repeated application of initially subthreshold electrical stimuli to brain regions like the amygdala or hippocampus gradually lowers seizure threshold until spontaneous seizures occur. This progressive increase in neural excitability serves as a widely used model for temporal lobe epilepsy and demonstrates activity-dependent plastic changes in neural circuits. Kindling involves long-lasting modifications in synaptic strength, ion channel expression, and network connectivity. The phenomenon appears extensively in epilepsy research and is used to study anticonvulsant mechanisms and seizure development.
Usage
Usage note: In neuroscience contexts, refers specifically to the seizure model, not the general meaning of starting a fire.
In Context
- "The kindling protocol successfully induced a chronic seizure state in the experimental animals." — Epilepsy research study
- "Anticonvulsant efficacy was tested using the well-established kindling model." — Pharmacological research paper