temporal summation
Integration of multiple synaptic inputs arriving at a neuron within a short time window.
Full Definition
Temporal summation is a fundamental mechanism of synaptic integration whereby multiple subthreshold synaptic inputs arriving at a neuron in rapid succession combine to produce a larger postsynaptic response. This process allows neurons to integrate information over time and is crucial for determining whether a neuron reaches its firing threshold. Temporal summation depends on the membrane time constant of the neuron and the frequency of incoming synaptic inputs. This mechanism is essential for neural computation and is altered in various neurological conditions affecting synaptic transmission.
Usage
Usage note: Distinguish from spatial summation, which involves simultaneous inputs from different locations.
In Context
- "The study examined how temporal summation properties change with aging in cortical neurons." — Electrophysiology research
- "Temporal summation of excitatory inputs was enhanced following long-term potentiation induction." — Synaptic plasticity study