therapeutic hypothermia
Controlled cooling intervention to reduce brain metabolism and secondary injury following cardiac arrest or severe brain trauma.
Full Definition
Therapeutic hypothermia is a neuroprotective intervention involving the controlled reduction of core body temperature, typically to 32-36°C, to reduce cerebral metabolic demands and limit secondary brain injury. This treatment is most commonly used following cardiac arrest with return of spontaneous circulation, where it has been shown to improve neurological outcomes. The cooling process must be carefully controlled to avoid complications such as arrhythmias, coagulopathy, or electrolyte disturbances. Temperature management includes induction, maintenance, and controlled rewarming phases. Modern protocols often use targeted temperature management rather than deep hypothermia, and the optimal target temperature continues to be refined through ongoing research.
Usage
Usage note: Distinguish from accidental hypothermia; always specify 'therapeutic' when referring to intentional cooling.
In Context
- "The cardiac arrest patient was started on therapeutic hypothermia protocol within two hours of return of spontaneous circulation." — clinical progress note
- "Therapeutic hypothermia guidelines recommend maintaining target temperature for 12-24 hours followed by controlled rewarming." — treatment protocol