PLEDS
Pronunciation: PLEDZ
Also written as: PLEDS — periodic lateralized epileptiform discharges
Periodic lateralized epileptiform discharges appearing as repetitive sharp waves or spikes over one hemisphere, indicating acute brain injury.
Full Definition
Periodic lateralized epileptiform discharges (PLEDS) are distinctive EEG patterns characterized by repetitive sharp waves, spikes, or spike-and-wave complexes that occur at regular intervals of 0.5-3 seconds over one cerebral hemisphere. PLEDS typically indicate acute destructive brain lesions such as stroke, encephalitis, or tumor and represent a state of cortical irritability with high seizure potential. The pattern may evolve over time, and patients with PLEDS have a significant risk of developing clinical seizures. PLEDS are considered an EEG emergency pattern requiring prompt medical attention and often anti-seizure medication prophylaxis.
Usage
Usage note: Modern terminology prefers 'lateralized periodic discharges (LPDs)' but PLEDS remains widely used.
In Context
- "PLEDS were noted over the left hemisphere with a frequency of 1.5 Hz in this stroke patient." — ICU EEG report
- "The appearance of PLEDS prompted initiation of prophylactic antiepileptic therapy." — Neurology consultation