chromogranin A level
Serum biomarker measurement used to detect, monitor, and assess treatment response in neuroendocrine tumors.
Full Definition
Chromogranin A level refers to the quantitative measurement of chromogranin A protein in serum or plasma, serving as a crucial biomarker for neuroendocrine tumors. Elevated levels can indicate the presence of neuroendocrine tumors, monitor disease progression, and assess treatment response. Normal ranges vary by laboratory, but levels are typically elevated in functioning and non-functioning neuroendocrine tumors. However, chromogranin A can also be elevated in non-neoplastic conditions such as renal failure, liver disease, inflammatory bowel disease, and with proton pump inhibitor use. Serial measurements are more valuable than single values for monitoring tumor behavior and treatment effectiveness.
Usage
Usage note: Capitalize 'A' when referring to the specific protein; use specific units (ng/mL or μg/L) when reporting values.
In Context
- "The chromogranin A level decreased from 150 to 45 ng/mL following octreotide treatment." — Laboratory monitoring report
- "An elevated chromogranin A level of 200 ng/mL supported the suspected neuroendocrine tumor diagnosis." — Clinical assessment