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In the Industry Vocabulary Test
chromogranin A
A glycoprotein marker used to identify neuroendocrine cells and tumors in clinical specimens.
Full Definition
Chromogranin A (CgA) is an acidic glycoprotein found in the secretory vesicles of neuroendocrine cells throughout the body. It serves as a reliable biomarker for diagnosing neuroendocrine tumors and monitoring treatment response. Elevated serum levels of CgA are commonly measured in clinical practice to assess neuroendocrine tumor burden. The protein is co-released with hormones during exocytosis and can be detected through immunohistochemical staining of tissue samples.
Usage
Usage note: Often abbreviated as CgA in clinical documentation.
In Context
- "Immunohistochemical staining for chromogranin A confirmed the neuroendocrine origin of the tumor." — Pathology report
- "Serial chromogranin A measurements showed a progressive decline following octreotide therapy." — Clinical follow-up note
Also known as
CgA
chromogranin-A
Don't confuse with
chromogranin B
synaptophysin