gastroenteropancreatic neuroendocrine tumor
Neuroendocrine tumor arising from the digestive system, including stomach, intestines, and pancreas.
Full Definition
Gastroenteropancreatic neuroendocrine tumors (GEP-NETs) are a diverse group of neuroendocrine tumors originating from the enterochromaffin cells and related neuroendocrine cells within the gastrointestinal tract and pancreas. These tumors are classified based on their anatomical location (foregut, midgut, hindgut), histological grade, and functional status. GEP-NETs may be functional, producing hormones that cause specific clinical syndromes, or non-functional. The WHO classification system grades these tumors based on proliferative activity (Ki-67 index and mitotic count). Treatment approaches include surgical resection, somatostatin analogs, peptide receptor radionuclide therapy, and systemic therapies depending on tumor characteristics and stage.
Usage
Usage note: Often abbreviated as GEP-NET; hyphenate the full term when used as compound modifier.
In Context
- "The pathology confirmed a grade 2 gastroenteropancreatic neuroendocrine tumor of the duodenum." — Pathology report
- "Octreotide therapy was initiated for the metastatic gastroenteropancreatic neuroendocrine tumor." — Treatment plan