mitotic count
Histological parameter counting mitotic figures per unit area, crucial for grading neuroendocrine tumors.
Full Definition
Mitotic count is a fundamental histopathological parameter that quantifies the number of mitotic figures (cells undergoing division) observed in a standardized area of tumor tissue, typically expressed as mitoses per 10 high-power fields (HPF) or per 2 square millimeters. In neuroendocrine tumor pathology, mitotic count is a critical component of the WHO grading system, used alongside Ki-67 proliferation index to classify tumors as Grade 1, 2, or 3. Accurate mitotic counting requires careful microscopic examination to distinguish true mitotic figures from apoptotic cells or artifacts. The mitotic count directly correlates with tumor aggressiveness and prognosis, making it essential for treatment planning and patient counseling.
Usage
Usage note: Always specify the area examined (per 10 HPF or per 2 mm²); distinguish from Ki-67 proliferation index.
In Context
- "The mitotic count of 4 per 10 HPF combined with Ki-67 of 8% confirmed a Grade 2 neuroendocrine tumor." — Pathology report
- "Careful examination revealed a mitotic count of 25 per 2 mm², indicating high-grade neuroendocrine carcinoma." — Histopathology assessment