paracrine signaling
Local cell communication where signaling molecules act on nearby target cells rather than distant organs via circulation.
Full Definition
Paracrine signaling is a form of cell communication in which neuroendocrine cells release signaling molecules that act on adjacent or nearby target cells within the same tissue or organ. Unlike endocrine signaling, which involves hormone transport through the bloodstream to distant targets, paracrine signals have local effects and typically have short half-lives. This type of signaling is particularly important in neuroendocrine tissues where it helps coordinate cellular responses, modulate hormone secretion, and maintain tissue homeostasis. Many neuropeptides and growth factors function as paracrine mediators in neuroendocrine systems.
Usage
Usage note: Distinguish clearly from endocrine (distant) and autocrine (self) signaling modes.
In Context
- "Somatostatin released from delta cells exerted paracrine signaling effects on neighboring insulin-producing beta cells." — research paper
- "The tumor's growth was influenced by paracrine signaling molecules produced by surrounding stromal cells." — oncology report