magnetization transfer
MRI technique that measures the exchange of magnetization between free water protons and macromolecules, providing tissue microstructural information.
Full Definition
Magnetization transfer is an advanced MRI contrast mechanism that exploits the interaction between mobile water protons and protons bound to macromolecules like proteins and lipids. By applying off-resonance radiofrequency pulses, the technique creates contrast that reflects tissue microstructural integrity. The magnetization transfer ratio (MTR) quantifies this effect and is particularly sensitive to myelin content and axonal density. This technique is valuable in multiple sclerosis research, where demyelination significantly reduces MTR values.
Usage
Usage note: Often abbreviated as MT in technical contexts; use full term in patient-facing documents.
In Context
- "Magnetization transfer imaging revealed reduced MTR in the normal-appearing white matter." — Research protocol
- "The study protocol included magnetization transfer sequences to assess myelin integrity." — Clinical trial documentation